Pedersen N S, Axelsen N H, Jørgensen B B, Petersen C S
Scand J Immunol. 1980;11(6):629-33. doi: 10.1111/j.1365-3083.1980.tb00031.x.
More than forty water-soluble antigens were found in the Reiter treponeme by crossed immunoelectrophoresis, using isolated and concentrated Ig from immunized rabbits. Five antigens reacted with antibodies in sera from selected patients with secondary syphilis, all having strong reactions in traditional tests for syphilis. No antibodies were found in selected healthy controls nonreactive in traditional syphilis tests. The five antigens represent available and potentially valuable antigens for development of new diagnostic syphilis tests. One of the antigens probably represents the axial filament. The findings open new possibilities for precise immunochemical studies of treponemes and of the immunology of syphilis.
通过交叉免疫电泳，利用从免疫兔中分离和浓缩的免疫球蛋白，在赖特尔密螺旋体中发现了四十多种水溶性抗原。五种抗原与选定的二期梅毒患者血清中的抗体发生反应，这些患者在传统梅毒检测中均有强反应。在传统梅毒检测中无反应的选定健康对照中未发现抗体。这五种抗原是开发新型梅毒诊断检测可用的且可能有价值的抗原。其中一种抗原可能代表轴丝。这些发现为密螺旋体及梅毒免疫学的精确免疫化学研究开辟了新的可能性。
