Boido V, Bennicelli C, Zanacchi P, De Flora S
Toxicol Lett. 1980 Oct;6(6):379-83. doi: 10.1016/0378-4274(80)90110-1.
Sodium nitrite and two primary aromatic amines, viz. amino antipyrine (AAP) and aniline, were preincubated in vitro with human gastric juice. The resulting derivatives -- presumably diazonium salts -- were directly mutagenic in the Salmonella test. The mutagenic response was more pronounced in the case of AAP, while toxic effects narrowed the range of activity of the aniline derivative. These patterns are consistent with the findings of independent colorimetric analyses, showing that the AAP derivative is more stable at 37 degrees C than the aniline derivative.
亚硝酸钠与两种伯芳香胺，即氨基安替比林（AAP）和苯胺，在体外与人胃液进行预孵育。所产生的衍生物——推测为重氮盐——在沙门氏菌试验中具有直接致突变性。AAP的致突变反应更为明显，而毒性作用则缩小了苯胺衍生物的活性范围。这些模式与独立的比色分析结果一致，表明AAP衍生物在37℃时比苯胺衍生物更稳定。
