Lycheva T A, Bondarenko V M, Burd G I, Umiarov A M, Bol'shakova T N
Zh Mikrobiol Epidemiol Immunobiol. 1980 Jun(6):58-63.
Sh. flexneri mutants No. 2a, resistant to phosphomycin (25 microgram/ml), differ in their fermentability in respect to glucose, mannitol, mannose and fructose. The mutants fall into 7 groups by this characteristic. All the resistant mutants, irrespective of the type of hydrocarbon fermentation, have lost their ability of causing keratoconjunctivitis. The decreased virulence of the phosphomycin-resistant mutants is linked with the loss of their penetration properties, although their adhesiveness and proliferative capacity on the surface HeLa cells is retained. A change in the virulence of the mutants under study is not connected with disturbances in the synthesis of O-antigen LPS. Most of these mutants are highly immunogenic.
福氏志贺菌2a号突变株对磷霉素（25微克/毫升）具有抗性，其在葡萄糖、甘露醇、甘露糖和果糖的发酵能力方面存在差异。根据这一特性，这些突变株可分为7组。所有抗性突变株，无论其烃发酵类型如何，都已失去引起角膜结膜炎的能力。磷霉素抗性突变株毒力的降低与其穿透特性的丧失有关，尽管它们在HeLa细胞表面的黏附性和增殖能力得以保留。所研究的突变株毒力的变化与O抗原脂多糖合成的紊乱无关。这些突变株中的大多数具有高度免疫原性。
