Phillips M, McAloon M H
Alcohol Clin Exp Res. 1980 Oct;4(4):391-5. doi: 10.1111/j.1530-0277.1980.tb04837.x.
We evaluated the sweat-patch test for its ability to detect alcohol consumption. During an 8-day study, volunteers drank whisky while wearing sweat-patches that collected sweat continuously at a steady rate. We offered 1.0, 2.0, or 5.0 g ethanol/kg/day to 6 continuous drinkers, and 5.0 g ethanol/kg/day for 2 days to 8 episodic drinkers, and removed sweat patches after 2, 4, 6, and 8 days. The concentration of ethanol in the collected sweat (Cs) rose: (1) progressively with the amount of alcohol consumed: and (2) linearly with the mean concentration of ethanol in the blood (Cb) during the sweat collection period (In Cs = 0.80 In Cb - 1.40; r = 0.93, p < 0.001). The test clearly distinguished drinkers from nondrinkers (Cs < 0.0022 G/L when no ethanol consumed; Cs > 0.0067 G/L when 0.5 G ethanol/kg/day consumed and when Cb > 0.013 G/L). The sweat patch test provides an objective index of drinking behavior with potential applications in clinical practice and research.
我们评估了汗液贴片测试检测酒精摄入的能力。在一项为期8天的研究中，志愿者们饮用威士忌的同时佩戴着以稳定速率持续收集汗液的汗液贴片。我们给6名持续饮酒者分别提供了1.0、2.0或5.0克乙醇/千克/天的量，给8名偶尔饮酒者提供了5.0克乙醇/千克/天的量，持续2天，并在2、4、6和8天后取下汗液贴片。收集到的汗液中乙醇浓度（Cs）上升：（1）随着酒精摄入量的增加而逐渐上升；（2）在汗液收集期间与血液中乙醇的平均浓度（Cb）呈线性关系（ln Cs = 0.80 ln Cb - 1.40；r = 0.93，p < 0.001）。该测试能清晰地区分饮酒者和不饮酒者（未摄入乙醇时Cs < 0.0022克/升；摄入0.5克乙醇/千克/天且Cb > 0.013克/升时Cs > 0.0067克/升）。汗液贴片测试提供了一种饮酒行为的客观指标，在临床实践和研究中具有潜在应用价值。
