Feig S A
Crit Rev Diagn Imaging. 1980;13(3):229-48.
This is the second in a three part series on the hypothetical risk from X-ray mammography. It will review those aspects of breast anatomy, histology, physiology, and pathology which are pertinent to radiation carcinogenesis. Radiation-induced breast cancers are histologically identical to the naturally occurring type in that they arise from the ductal epithelium and consist of a similar proportion of infiltrating and intraductal lesions. As indicated from mortality/incidence ratios, their prognosis is no worse, and may even be better, than that of naturally occurring lesions. Their location within the breast may depend on the distribution of absorbed radiation. Possible explanations for the increased resistance to radiation effect in women over 30 years of age at time of exposure will be evaluated. these include regression of the glandular target tissue, hormonal changes, and parity. Examples of age-related sensitivity and hormonal dependence in other radiation-induced human and animal tumors will be discussed.
这是关于X线乳腺摄影术潜在风险的系列文章三部曲中的第二篇。它将回顾与辐射致癌作用相关的乳房解剖学、组织学、生理学和病理学的那些方面。辐射诱发的乳腺癌在组织学上与自然发生的类型相同，因为它们起源于导管上皮，并且浸润性和导管内病变的比例相似。从死亡率/发病率比率来看，它们的预后并不比自然发生的病变差，甚至可能更好。它们在乳房内的位置可能取决于吸收辐射的分布。将评估对30岁以上女性在暴露时对辐射效应抵抗力增加的可能解释。这些包括腺靶组织的退化、激素变化和生育情况。将讨论在其他辐射诱发的人类和动物肿瘤中与年龄相关的敏感性和激素依赖性的例子。
