Den Otter W, Merchant T E, Beijerinck D, Koten J W
Department of Functional Morphology, School of Veterinary Medicine, University of Utrecht, The Netherlands.
Anticancer Res. 1996 Sep-Oct;16(5B):3173-5.
Breast cancer induction due to mammographic screening has aroused considerable controversy in the discussion of the safety of this procedure. We have attempted to shed some light on this problem by approaching it from both a theoretical and a mathematical point of view. We found that about 99% of mammographically induced breast cancers occur in the group of women who are carriers of a breast cancer gene. Our calculations suggest that in women with an inherited gene for breast cancer an extra tumour in one out of 10 women will be induced by 20 mammographical examinations. On the other hand, mammography is safe for non-gene carriers.
乳腺钼靶筛查导致乳腺癌引发了关于该检查安全性讨论中的诸多争议。我们试图从理论和数学角度来阐明这个问题。我们发现，约99%的由乳腺钼靶检查诱发的乳腺癌发生在携带乳腺癌基因的女性群体中。我们的计算表明，对于携带遗传性乳腺癌基因的女性，20次乳腺钼靶检查会在每10名女性中诱发1例额外肿瘤。另一方面，乳腺钼靶检查对非基因携带者是安全的。
