Komabayashi T, Sakamoto S, Tsuboi M
Nihon Yakurigaku Zasshi. 1978 May;74(4):459-66.
Effects of procaine and xylocaine on the lipolytic actions caused by catecholamines and methylxanthine derivatives in white adipose tissues from rats were investigated. Both procaine and xylocaine remarkably inhibited the lipolyses caused by norepinephrine, epinephrine, caffeine and theophylline. Xylocaine inhibited the lipolysis more strongly than procaine, and also inhibited the basal lipolysis. The inhibition by either procaine or xylocaine appeared 60 minutes after the addition of the norepinephrine-induced lipolytic action. The antilipolytic action of procaine was evident in medium containing 2 mM EDTA instead of Ca2+, and its antilipolytic action was accelerated by increasing Ca2+ concentration in the medium. From these positive results, we suggest that both procaine and xylocaine have an antilipolytic effect, and this effect is closely dependent on the Ca2+ concentration in the medium.
研究了普鲁卡因和利多卡因对大鼠白色脂肪组织中儿茶酚胺和甲基黄嘌呤衍生物引起的脂解作用的影响。普鲁卡因和利多卡因均显著抑制去甲肾上腺素、肾上腺素、咖啡因和茶碱引起的脂解作用。利多卡因比普鲁卡因更强烈地抑制脂解作用，并且还抑制基础脂解作用。在加入去甲肾上腺素诱导的脂解作用60分钟后，普鲁卡因或利多卡因均出现抑制作用。在含有2 mM EDTA而非Ca2+的培养基中，普鲁卡因的抗脂解作用明显，并且通过增加培养基中Ca2+的浓度可加速其抗脂解作用。基于这些阳性结果，我们认为普鲁卡因和利多卡因均具有抗脂解作用，并且这种作用紧密依赖于培养基中的Ca2+浓度。
