Fluorimetric screening of dapsone in urine for drug trials.

The DDS/Crestinine ratios obtained by the colorimetric and fluorimetric methods for dapsone were compared in healthy controls, out-patients not claiming to have DDS treatment and inpatients receiving DDS. The ratios by fluorimetric method were considerably lower in the untreated cases compared to the colorimetric method. Fluorimetric assay for dapsone in urine can be more advantageously and reliably used for the preliminary screening of dapsone in urine for drug trials.