Peters C R, Shaw T E, Raju D R
Ann Plast Surg. 1980 Nov;5(5):347-52. doi: 10.1097/00000637-198011000-00003.
An attempt was made to determine if the tissue response to surgical trauma and foreign body stimulus (silicone implants) could be altered using vitamin E in rats. The animals were divided into four groups: Group A served as controls, Group B were treated by intramuscular vitamin E, Group C were treated topically with vitamin E around the prosthesis, and Group D were treated topically with croton oil around the prosthesis. The animals in each group were killed at 2 week, 1 month, and 3 months intervals. The intraprosthetic pressure in each prosthesis was recorded using a strain gauge transducer. The capsules were then removed and examined histologically using a light microscope and the thickness of pseudocapsules was measured with an ocular micrometer. In Group B significantly thinner pseudocapsules were observed at 2 weeks, but there was no comparable difference either in thickness or degree of contracture (as measured by intraprosthetic pressures) between Groups A and B at 2 months and 3 months. In Group C, the pseudocapsules were significantly thicker at all tested periods and showed noticeable contracture at 3 months. In group D the pseudocapsules were thickest and cellular infiltrate more marked than in the other groups.
研究人员试图确定在大鼠中使用维生素E是否可以改变组织对外科创伤和异物刺激（硅胶植入物）的反应。将动物分为四组：A组作为对照组，B组通过肌肉注射维生素E进行治疗，C组在假体周围局部使用维生素E进行治疗，D组在假体周围局部使用巴豆油进行治疗。每组动物分别在2周、1个月和3个月的间隔时间处死。使用应变片传感器记录每个假体内的压力。然后取出包膜，用光学显微镜进行组织学检查，并用目镜测微计测量假包膜的厚度。在B组中，在2周时观察到假包膜明显更薄，但在2个月和3个月时，A组和B组之间在厚度或挛缩程度（通过假体内压力测量）方面没有可比差异。在C组中，在所有测试时间段假包膜都明显更厚，并且在3个月时出现明显挛缩。在D组中，假包膜最厚，细胞浸润比其他组更明显。
