Kumar A, Shapiro A P
Arch Intern Med. 1980 Dec;140(12):1631-4.
Exacerbation of hypertension and a marked excretion of protein in the urine were observed in three patients in the absence of underlying renal parenchymal disease or other causes of proteinuria. Stenosis of a renal artery and hyperreninemia were present in all three patients. Correction of the stenosis by arterial bypass or nephrectomy resulted in a rapid decrease in urinary protein excretion. The relationship between the levels of renin activity and the proteinuria in one patient and long-term follow-up in the other two patients are reported, and the mechanisms of this proteinuria are reviewed. Renal artery stenosis may be the underlying cause in some cases of idiopathic nephrotic syndrome.
在三名患者中观察到高血压加重和明显的蛋白尿排泄，这些患者不存在潜在的肾实质疾病或其他蛋白尿原因。所有三名患者均存在肾动脉狭窄和高肾素血症。通过动脉搭桥或肾切除术纠正狭窄后，尿蛋白排泄迅速减少。报告了一名患者肾素活性水平与蛋白尿之间的关系以及另外两名患者的长期随访情况，并对这种蛋白尿的机制进行了综述。肾动脉狭窄可能是某些特发性肾病综合征病例的潜在病因。
