Weninger M, Widhalm K, Strobl W, Schernthaner G
Artery. 1980;8(2):185-90.
In 15 grossly obese children (10 boys, 5 girls, age: 13,1 +/- 2,4 years, mean overweight 71 +/- 13%) an oral glucose load (45 g/m2) was performed. Blood glucose was determined by means of hexokinase method and serum insulin was estimated by radioimmunoassay. According to the criteria of Rosenbloom our results show, that 5 out of the 15 children must be considered to have abnormal glucose tolerance tests. In comparison to reference values basal serum insulin values were slightly elevated, the corespondending concentrations after the oral glucose load were markedly increased in all children. Furthermore, serum lipoprotein determinations were performed using the Lipid-Research-Clinics-Method, NIH, Bethesda: Comparing the mean LDL-cholesterol and HDL-cholesterol concentrations with those of age and sex matched controls no statistical differences could be found. However, the HDL-cholesterol values showed a tendency towards lower concentrations. Our data suggest that disturbances of carbohydrate metabolism in grossly obese children could be only detected after the performance of an oral glucose tolerance test.
对15名严重肥胖儿童（10名男孩，5名女孩，年龄：13.1±2.4岁，平均超重71±13%）进行了口服葡萄糖负荷试验（45g/m²）。采用己糖激酶法测定血糖，放射免疫法测定血清胰岛素。根据罗森布鲁姆的标准，我们的结果显示，15名儿童中有5名必须被认为糖耐量试验异常。与参考值相比，基础血清胰岛素值略有升高，所有儿童口服葡萄糖负荷后的相应浓度均显著增加。此外，使用美国国立卫生研究院贝塞斯达脂质研究诊所的方法进行血清脂蛋白测定：将平均低密度脂蛋白胆固醇和高密度脂蛋白胆固醇浓度与年龄和性别匹配的对照组进行比较，未发现统计学差异。然而，高密度脂蛋白胆固醇值有降低的趋势。我们的数据表明，严重肥胖儿童的碳水化合物代谢紊乱只有在进行口服葡萄糖耐量试验后才能被检测到。
