Boer H H, Schot L P, Veenstra J A, Reichelt D
Cell Tissue Res. 1980;213(1):21-7. doi: 10.1007/BF00236917.
With an antiserum to the molluscan cardio-excitatory tetrapeptide FMRF-amide neurons and/or nerve fibers were immunocytochemically identified in the central nervous systems of a snail (Lymnaea stagnalis), some insects (Leptinotarsa decemlineata, Periplaneta americana, Locusta migratoria, Pieris brassicae), a fish (Poecilia latipinna) and a mammal (mouse). The fact that immunoreactive material was observed in neurohaemal organs (corpora cardiaca of the insects) as well as in axon terminals ending on other neurons, seems to indicate that this peptide can function as a neurohormone and/or as a neurotransmitter. The results sustain the hypothesis that biologically active peptides have a wide distribution in the animal kingdom.
用针对软体动物心脏兴奋四肽FMRF酰胺的抗血清，在蜗牛（椎实螺）、一些昆虫（马铃薯甲虫、美洲大蠊、飞蝗、粉蝶）、一种鱼类（帆鳍花鳉）和一种哺乳动物（小鼠）的中枢神经系统中，通过免疫细胞化学方法鉴定出了神经元和/或神经纤维。在神经血器官（昆虫的心侧体）以及终止于其他神经元的轴突终末中观察到免疫反应性物质，这一事实似乎表明该肽可以作为神经激素和/或神经递质发挥作用。这些结果支持了生物活性肽在动物界广泛分布的假说。
