昆虫神经分泌系统的胰高血糖素样和胰岛素样激素。
Glucagon-like and insulin-like hormones of the insect neurosecretory system.
作者信息
Tager H S, Markese J, Kramer K J, Speirs R D, Childs C N
出版信息
Biochem J. 1976 Jun 15;156(3):515-20. doi: 10.1042/bj1560515.
Abstract
Aqueous extracts of corpus cardiacum-corpus allatum complexes of the adult tobacco hornworm Manduca sexta produced both glycogenolysis and hypoglycaemia when injected into the larval form of the same species. Application of specific radioimmuno assays to similar extracts showed also that these gland complexes contain both glucagon-like and insulin-like peptides. Further, the partially purified immunoreactive peptides had the expected biological activities. The former decreased the glycogen content of the fatbody and the latter the circulating trehalose levels in recipient animals. These results suggest the existence of hormones in these invertebrates having both biological and structural similarities to vertebrate insulin and glucagon.
摘要
将成年烟草天蛾烟草天蛾的心侧体 - 咽侧体复合体的水提取物注射到同一物种的幼虫体内时，会产生糖原分解和低血糖现象。对类似提取物进行特定放射免疫测定表明，这些腺体复合体同时含有胰高血糖素样肽和胰岛素样肽。此外，部分纯化的免疫反应性肽具有预期的生物学活性。前者降低了受体动物脂肪体中的糖原含量，后者降低了循环海藻糖水平。这些结果表明，这些无脊椎动物中存在与脊椎动物胰岛素和胰高血糖素在生物学和结构上都相似的激素。
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