Aronow W S, Plasencia G, Wong R, Landa D
Clin Pharmacol Ther. 1981 Feb;29(2):155-9. doi: 10.1038/clpt.1981.25.
Eight patients who improved their exercise duration to angina or marked fatigue (greater than or equal to 25%) on timolol 10 to 30 mg twice daily over that on placebo 8 to 14 mo previously were subjects in a double-blind, randomized, crossover 4-wk study of the effect of timolol on exercise duration 2 and 12 hr after medication. One patient was discontinued from the study because unstable angina developed on placebo. Mean exercise duration on timolol over control was increased at 12 hr (p less than 0.02) and at 2 hr ( p less than 0.001) after drug. There was an increase in exercise duration greater than or equal to 25% on timolol over control compared with placebo in three of seven patients (43%) 12 hr after drug and in seven of seven (100%) 2 hr after drug. Timolol 10 to 30 mg twice daily prolongs exercise duration to angina or marked fatigue at 2 hr after drug and in some responders at 12 hr after drug.
八名患者之前在服用安慰剂8至14个月期间，运动至心绞痛或明显疲劳的时长为[具体时长未提及]，而当他们每日两次服用10至30毫克噻吗洛尔后，运动时长得到改善（提高了25%及以上）。这八名患者参与了一项为期4周的双盲、随机、交叉研究，该研究旨在探究服用噻吗洛尔后2小时和12小时对运动时长的影响。一名患者因在服用安慰剂期间出现不稳定型心绞痛而退出研究。服用药物后，与对照组相比，噻吗洛尔组在12小时（p<0.02）和2小时（p<0.001）时的平均运动时长增加。服药12小时后，七名患者中有三名（43%）、服药2小时后，七名患者中有七名（100%），与服用安慰剂的对照组相比，服用噻吗洛尔后运动时长增加了25%及以上。每日两次服用10至30毫克噻吗洛尔可使服药后2小时运动至心绞痛或明显疲劳的时长延长，部分反应者在服药12小时后也有此效果。
