内源性胰高血糖素对十二指肠溃疡患者壁细胞迷走神经切断术前、后胃酸分泌的影响。
Effect of endogenous pancreatic glucagon on gastric acid secretion in patients with duodenal ulcer before and after parietal cell vagotomy.
作者信息
Loud F B, Chirstiansen J, Holst J J, Petersen B, Kirkegaard P
出版信息
Gut. 1981 May;22(5):359-62. doi: 10.1136/gut.22.5.359.
Abstract
The effect of endogenous pancreatic glucagon on submaximal pentagastrin stimulated gastric acid secretion was studied by infusion of 1-arginine in patients with duodenal ulcer before and after parietal cell vagotomy without drainage (PCV). Preoperatively infusion of 1-arginine resulted in a marked inhibition of acid secretion, whereas no effect was found postoperatively. Plasma glucagon concentrations were identical pre- and postoperatively, fasting as well as during arginine infusion. Serum gastrin concentration rose after PCV but not unaffected by arginine infusion both pre- and postoperatively. The study demonstrates that intact vagal innervation of the fundic glands is a condition of inhibition of pentagastrin induced acid secretion by pancreatic glucagon released by infusion of 1-arginine.
摘要
在无引流的壁细胞迷走神经切断术（PCV）前后，通过向十二指肠溃疡患者输注L-精氨酸，研究内源性胰高血糖素对次最大剂量五肽胃泌素刺激胃酸分泌的影响。术前输注L-精氨酸可显著抑制胃酸分泌，而术后未发现此作用。术前和术后，空腹及精氨酸输注期间血浆胰高血糖素浓度相同。PCV后血清胃泌素浓度升高，但术前和术后均不受精氨酸输注的影响。该研究表明，胃底腺完整的迷走神经支配是输注L-精氨酸释放的胰高血糖素抑制五肽胃泌素诱导胃酸分泌的一个条件。
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本文引用的文献
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Scand J Gastroenterol. 1980;15(6):711-4. doi: 10.3109/00365528009181519.
2
Prospective controlled vagotomy trial for duodenal ulcer: primary results, sequelae, acid secretion, and recurrence rates two to five years after operation.十二指肠溃疡前瞻性对照迷走神经切断术试验：手术两至五年后的主要结果、后遗症、胃酸分泌及复发率
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Evidence that glicentin contains the entire sequence of glucagon.胃泌酸调节素包含胰高血糖素完整序列的证据。
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Clin Chem. 1972 Mar;18(3):299-300.
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