迷走神经切断术对人体十二指肠内渗透压物质引起的胃分泌反应的影响。
Effect of vagotomy on the gastric secretory response to intraduodenal osmotic agents in man.
作者信息
Ward A S
出版信息
Gut. 1976 Jan;17(1):48-53. doi: 10.1136/gut.17.1.48.
Abstract
The effect of intraduodenal infusion of hypertonic saline and glucose on pentagastrin-stimulated gastric secretion was investigated in 35 normal subjects, 32 duodenal ulcer patients and 32 patients after truncal vagotomy and pyloroplasty. A significant gastric inhibitory response occurred after 0.51 M saline and 1-03 M glucose in the normal subjects and duodenal ulcer patients but after vagotomy there was no inhibition. This finding suggests that the inhibitory effect of these agents depends, at least in part, on a vagal reflex in man. The response to very high glucose concentrations persisted after vagotomy and it seems likely that a humoral mechanism may be involved in this situation.
摘要
在35名正常受试者、32名十二指肠溃疡患者以及32名接受了迷走神经切断术和幽门成形术的患者中，研究了十二指肠内输注高渗盐水和葡萄糖对五肽胃泌素刺激的胃酸分泌的影响。正常受试者和十二指肠溃疡患者在输注0.51M盐水和1.03M葡萄糖后出现显著的胃抑制反应，但迷走神经切断术后则无抑制作用。这一发现表明，这些药物的抑制作用至少部分取决于人体的迷走神经反射。迷走神经切断术后对极高葡萄糖浓度的反应仍然存在，在这种情况下似乎可能涉及一种体液机制。
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THE INSULIN TEST AFTER VAGOTOMY.迷走神经切断术后的胰岛素试验。
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Laboratory criteria for the completeness of vagotomy.迷走神经切断术完整性的实验室标准。
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