Watanabe S, Yokoyama S, Kubo S, Iwai H, Kuyama C
Folia Psychiatr Neurol Jpn. 1980;34(2):147-56. doi: 10.1111/j.1440-1819.1980.tb01523.x.
In conducting the double-blind controlled study of antidepressants, observations were carried out on the relationship between Maprotiline/Desmethylmaprotiline, concentrations in blood and antidepressive effects, the doses and the incidence of side effects. 1) The maprotiline concentration in the effective group (markedly improved + moderately improved) was 306.9 +/- 112.9 ng/ml, and 244.4 +/- 43.0 ng/ml in the non-effective group (slightly improved + unchanged + aggavated). There was no statistically difference between both groups. 2) Correlations of the maprotiline concentration in blood and together with desmethylmaprotiline to the efficacy (the variation rates in Hamilton's scores) showed a tendency toward higher concentrations in blood with higher therapeutic responses. 3) Side effects were observed in all of the patients with the concentration in blood higher than the mean value (265.2 ng/ml).
在进行抗抑郁药的双盲对照研究时，对麦普替林/去甲麦普替林的血药浓度与抗抑郁效果、剂量及副作用发生率之间的关系进行了观察。1）有效组（显著改善+中度改善）的麦普替林浓度为306.9±112.9 ng/ml，无效组（轻度改善+无变化+加重）为244.4±43.0 ng/ml。两组之间无统计学差异。2）麦普替林血药浓度及去甲麦普替林与疗效（汉密尔顿评分变化率）的相关性显示，血药浓度越高，治疗反应越高。3）所有血药浓度高于平均值（265.2 ng/ml）的患者均观察到副作用。
