Haftek M, Ortonne J P, Staquet M J, Viac J, Thivolet J
J Invest Dermatol. 1981 Jan;76(1):48-52. doi: 10.1111/1523-1747.ep12524864.
124 normal and psoriatic human skin grafts were performed on congenitally athymic nude mice. 5, 10, 15, 20, and 30 days after grafting, histological and immunochemical studies (using bullous pemphigoid, pemphigus vulgaris and anti 67 K keratin polypeptide immune sera) were performed. The preservation of certain immunological identities of grafted skin, at least with regard to intercellular substance and basement membrane, was observed and the keratinization pattern of human epidermis also remained unaltered throughout the post-grafting period. The typical clubbing of rate ridges/acanthosis pattern in psoriatic skin was preserved in 40% of involved psoriatic skin grafts. The possible significance of these findings is discussed.
将124块正常和银屑病患者的人类皮肤移植到先天性无胸腺裸鼠身上。移植后5、10、15、20和30天，进行了组织学和免疫化学研究（使用大疱性类天疱疮、寻常型天疱疮和抗67K角蛋白多肽免疫血清）。观察到移植皮肤的某些免疫特性得以保留，至少在细胞间物质和基底膜方面如此，并且在移植后的整个时期，人类表皮的角化模式也保持不变。在40%的受累银屑病皮肤移植中，银屑病皮肤典型的嵴状隆起/棘皮症模式得以保留。讨论了这些发现的可能意义。
