Gay S, Kresina T F, Gay R, Miller E J, Montes L F
J Cutan Pathol. 1979 Apr;6(2):91-5. doi: 10.1111/j.1600-0560.1979.tb01108.x.
Antibodies prepared against the collagen C-chain derived from human placenta specifically strain the epidermal basement membrane of normal human skin as well as the basement membrane surrounding the skin appendages and capillaries. Using the antibodies, it was observed that all basement membranes in untreated psoriatic plaques appear fragmented and separted into several layers. The results suggest that psoriatic lesions are associated with a general loss of basement membrane integrity which may play a crucial role in the pathogenesis of the disease.
针对源自人胎盘的胶原蛋白C链制备的抗体，能特异性地使正常人皮肤的表皮基底膜以及皮肤附属器和毛细血管周围的基底膜着色。使用这些抗体观察到，未经治疗的银屑病斑块中的所有基底膜均出现断裂并分成几层。结果表明，银屑病皮损与基底膜完整性的普遍丧失有关，这可能在该疾病的发病机制中起关键作用。
