Klevay L M
J Environ Pathol Toxicol. 1980 Sep;4(2-3):281-7.
The zinc/copper hypothesis, which invokes relative or absolute deficiency of copper in the etiology of ischemic heart disease, was described. The belief that calcium (and, perhaps, magnesium) is a substance in hard water which protects against ischemic heart disease by altering copper and zinc metabolism was presented. The amounts of copper and zinc in drinking water usually are too small to produce important increases in the amounts of these elements in diets. Occasionally tap water high in copper may be an important supplement to a diet low in copper.
文中描述了锌/铜假说，该假说认为缺血性心脏病的病因与铜的相对或绝对缺乏有关。文中还提到一种观点，即钙（或许还有镁）是硬水中的一种物质，它通过改变铜和锌的代谢来预防缺血性心脏病。饮用水中铜和锌的含量通常过低，无法使饮食中这些元素的含量显著增加。偶尔，铜含量高的自来水可能是低铜饮食的重要补充。
