Klevay L M
USDA, ARS, Grand Forks Human Nutrition Research Center, North Dakota 58202.
J Trace Elem Electrolytes Health Dis. 1993 Jun;7(2):63-9.
There are many diseases of unknown etiology. Increasingly vibrant, contemporary research is attempting to associate trace element metabolism with some of these illnesses. Because trace elements can produce profound effects on health via enzymes, hormones and messenger molecules, analytical assessment must be directed toward these chemicals as well as to the trace elements. Element analysis may be directed best toward specific cells, tissues and organs. Copper deficiency is associated with the etiology, pathogenesis and pathophysiology of ischemic heart disease via metabolic processes affecting cardiovascular health. Some drugs now used to treat heart disease affect copper metabolism but many other metabolic processes are unaffected by deficiency. It seems prudent to avoid diets containing amounts of copper that have been proved insufficient for people in controlled experiments.
有许多病因不明的疾病。当代研究日益活跃，正试图将微量元素代谢与其中一些疾病联系起来。由于微量元素可通过酶、激素和信使分子对健康产生深远影响，分析评估必须针对这些化学物质以及微量元素。元素分析最好针对特定的细胞、组织和器官。铜缺乏通过影响心血管健康的代谢过程与缺血性心脏病的病因、发病机制和病理生理学相关。目前一些用于治疗心脏病的药物会影响铜代谢，但许多其他代谢过程不受铜缺乏的影响。避免食用在对照实验中已被证明对人体铜含量不足的饮食似乎是明智的。
