L-谷氨酰胺对胰岛素释放的刺激作用。
Stimulation of insulin release by L-glutamine.
作者信息
Sener A, Malaisse W J
出版信息
Mol Cell Biochem. 1980 Dec 16;33(3):157-9. doi: 10.1007/BF00225288.
PMID:7007870
Abstract
Under normal environmental conditions, L-glutamine is well oxidized but fails to stimulate insulin release in rat pancreatic islets. However, a marked stimulation of insulin release by L-glutamine, without alteration in its oxidation rate occurs when the intracellular pH of the islet cells is decreased and/or when theophylline is added to the incubation medium.
摘要
在正常环境条件下，L-谷氨酰胺能很好地被氧化，但在大鼠胰岛中却不能刺激胰岛素释放。然而，当胰岛细胞的细胞内pH值降低和/或在孵育培养基中加入茶碱时，L-谷氨酰胺会显著刺激胰岛素释放，而其氧化速率没有改变。
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