前列环素对血小板因子3活性的抑制作用。

Inhibition of platelet factor 3 availability by prostacyclin.

作者信息

Hársfalvi J, Muszbek L, Stadler I, Fésüs L

出版信息

Prostaglandins. 1980 Nov;20(5):935-45. doi: 10.1016/0090-6980(80)90143-4.

Abstract

Preincubation of human platelet rich plasma with PGI2 in a concentration preventing collagen induced platelet aggregation abolished also platelet factor 3 availability brought about by collagen. Following PGI2 pretreatment no second wave aggregation could be elicited by ristocetin. However, primary aggregation as well as platelet factor 3 activity were only partially inhibited in this case and the inhibitory action of PGI2 was not increased by raising its concentration. Similarly, marked but not complete inhibition of platelet factor 3 availability was obtained when kaolin was used as activating agent.

摘要

将富含人血小板的血浆与前列环素（PGI2）进行预温育，当PGI2浓度能防止胶原诱导的血小板聚集时，由胶原引起的血小板第3因子有效性也会消失。PGI2预处理后，瑞斯托菌素不能引发第二波聚集。然而，在这种情况下，初级聚集以及血小板第3因子活性仅被部分抑制，并且提高PGI2浓度并不能增强其抑制作用。同样，当用高岭土作为激活剂时，血小板第3因子有效性会受到显著但不完全的抑制。