Goto T, Abe K, Tsunoda K, Seino M, Yasujima M, Imai Y, Chiba S, Sato M, Haruyama T, Omata K
Tohoku J Exp Med. 1986 Jun;149(2):169-81. doi: 10.1620/tjem.149.169.
The changes in active and inactive renin after captopril (n = 29) or furosemide administration (n = 10) were studied in hypertensive patients. Furthermore, after percutaneous transluminal angioplasty (PTA) in 3 cases of renovascular hypertension (RVH), and after nephrectomy in a case of juxtaglomerular cell tumor, the time course of the changes in these two types of renin was investigated. Inactive renin was activated by trypsin treatment. Plasma renin concentration was measured by using an excess of sheep substrate. In patients with essential hypertension or primary aldosteronism, inactive renin was unchanged, irrespective of response in active renin, after the administration of captopril and furosemide. In patients with RVH, inactive renin was markedly decreased by furosemide but unchanged by captopril, in spite of significant increase in active renin. After PTA and nephrectomy, inactive renin decreased slower than active renin. These data support the idea that in patients with RVH, the increase in active renin by furosemide is at least partly due to the activation of inactive renin. It is also suggested that the increase in active renin by captopril is mainly due to the promoted release of active renin from the kidney. Furthermore, it seems likely that the metabolic clearance of inactive renin is slower than that in active renin.
在高血压患者中研究了服用卡托普利（n = 29）或呋塞米（n = 10）后活性肾素和非活性肾素的变化。此外，在3例肾血管性高血压（RVH）患者经皮腔内血管成形术（PTA）后，以及在1例肾小球旁细胞瘤患者肾切除术后，研究了这两种肾素变化的时间进程。非活性肾素经胰蛋白酶处理后被激活。血浆肾素浓度采用过量的绵羊底物进行测定。在原发性高血压或原发性醛固酮增多症患者中，服用卡托普利和呋塞米后，无论活性肾素的反应如何，非活性肾素均无变化。在RVH患者中，尽管活性肾素显著增加，但呋塞米可使非活性肾素明显降低，而卡托普利对其无影响。PTA和肾切除术后，非活性肾素的下降比活性肾素慢。这些数据支持以下观点：在RVH患者中，呋塞米使活性肾素增加至少部分是由于非活性肾素的激活。还提示卡托普利使活性肾素增加主要是由于促进了活性肾素从肾脏的释放。此外，非活性肾素的代谢清除似乎比活性肾素慢。
