Aeschbacher H U, Würzner H P
Toxicol Lett. 1980 Feb;5(2):139-45. doi: 10.1016/0378-4274(80)90163-0.
High concentrations of "home brew" and instant coffe induced revertants 2--3-fold the spontaneous level with the Ames Salmonella tester strain TA 100 but not with the strains TA 98, TA 1535, TA 1537 and TA 1538. This borderline effect, which may also have been due to non-mutagenic interactions (false positives) occurred only at bacterial levels of coffees and was completely abolished in the presence of the microsomal "metabolic activation system". Negative results were obtained in host-mediated assays when mice received up to 6 g instant coffee/kg body weight. An extrapolation in respect of possible carcinogenic risks is dubious.
高浓度的“自酿啤酒”和速溶咖啡在使用鼠伤寒沙门氏菌测试菌株TA 100时可诱导回复突变体数量达到自发水平的2至3倍，但使用菌株TA 98、TA 1535、TA 1537和TA 1538时则不然。这种临界效应，可能也是由于非诱变相互作用（假阳性）引起的，仅在咖啡的细菌水平上出现，并且在存在微粒体“代谢激活系统”的情况下完全消除。当小鼠接受高达6克/千克体重的速溶咖啡时，宿主介导试验得到阴性结果。关于可能的致癌风险的推断是可疑的。
