Vajaradul Y
Clin Ther. 1981;3(5):336-43.
Fifty-four outpatients with gonarthrosis participated in a double-blind clinical test with the aim of evaluating the efficacy and tolerance of intra-articular glucosamine in comparison with a 0.9% NaCl placebo. Each patient had one intra-articular injection per week for five consecutive weeks. Pain, active and passive mobility of the joint, swelling, and generalized and local intolerance symptoms were recorded before beginning the treatment, and four weeks after the last injection. glucosamine reduced pain to a significantly greater extent than did placebo, and resulted in significantly more pain-free patients. The angle of joint flexion substantially increased after glucosamine treatment. Active mobility increased with both treatments, with a more favorable trend after glucosamine administration. Knee swelling did not decrease significantly after glucosamine, whereas it worsened (although no significantly) after placebo. There were no local or general intolerance symptoms during and after treatment. Glucosamine administration was able to accelerate the recovery of arthrosic patients, with no resulting side effects, and to partially restore articular function. In addition, the clinical recovery did not fade after treatment ended, but lasted for the following month, at least. These features are a definite improvement over antirheumatic drugs, the major drawbacks of which are action of short duration and side effects. Glucosamine therapy therefore deserves a selected place in the management of osteoarthrosis.
54名膝关节炎门诊患者参与了一项双盲临床试验，目的是评估关节内注射氨基葡萄糖与0.9%氯化钠安慰剂相比的疗效和耐受性。每位患者连续五周每周进行一次关节内注射。在治疗开始前以及最后一次注射后四周，记录疼痛、关节的主动和被动活动度、肿胀情况以及全身和局部不耐受症状。与安慰剂相比，氨基葡萄糖能更显著地减轻疼痛，且产生无疼痛患者的比例显著更高。氨基葡萄糖治疗后关节屈曲角度大幅增加。两种治疗方法均使主动活动度增加，氨基葡萄糖给药后趋势更有利。氨基葡萄糖治疗后膝关节肿胀未显著减轻，而安慰剂治疗后肿胀虽未显著加重但有所恶化。治疗期间及治疗后均未出现局部或全身不耐受症状。氨基葡萄糖给药能够加速关节病患者的康复，且无副作用，并能部分恢复关节功能。此外，治疗结束后临床康复并未消退，而是至少持续了接下来的一个月。这些特性相较于抗风湿药物有明显改善，抗风湿药物的主要缺点是作用持续时间短和有副作用。因此，氨基葡萄糖疗法在骨关节炎的治疗中值得占据一席之地。
