关节软骨病理学与硫酸氨基葡萄糖的应用综述。
A review of articular cartilage pathology and the use of glucosamine sulfate.
机构信息
University of Hartford, Hartford, CT.
出版信息
J Athl Train. 2001 Oct;36(4):413-9.
OBJECTIVE
To refresh the athletic trainer's knowledge of articular cartilage biomechanics, physiology, and structure and explore the role of glucosamine sulfate in treating articular cartilage pathologic conditions, including supplementation methods and clinical outcomes.
DATA SOURCES
We searched MEDLINE from 1989 through 2000 and SPORT Discus from 1975 through 2000 using the following key words: glucosamine sulfate, articular cartilage, osteoarthritis, and proteoglycans.
DATA SYNTHESIS
Articular cartilage functions as a wear-resistant, smooth, nearly frictionless, load-bearing surface. Glucosamine sulfate can be thought of as a building block that helps restore the proteoglycan-rich extracellular matrix and thus balance articular cartilage catabolism and anabolism. Beneficial clinical effects of glucosamine sulfate in the osteoarthritic population have been documented. However, the use of glucosamine sulfate for athletic articular cartilage injuries is unproved.
CONCLUSIONS/RECOMMENDATIONS: Clinical studies indicate that glucosamine sulfate has been shown to be a safe and relatively effective treatment for osteoarthritis. However, no evidence to date supports or refutes a carryover effect to the athletic population and the injuries that occur in sport.
目的
更新运动医学治疗师对关节软骨生物力学、生理学和结构的认识，探讨硫酸氨基葡萄糖在治疗关节软骨病理状况中的作用，包括补充方法和临床效果。
资料来源
我们使用以下关键词在 MEDLINE（1989 年至 2000 年）和 SPORT Discus（1975 年至 2000 年）进行了检索：硫酸氨基葡萄糖、关节软骨、骨关节炎和蛋白聚糖。
资料综合
关节软骨起到耐磨、光滑、几乎无摩擦、承重的作用。可以将硫酸氨基葡萄糖视为一种有助于恢复富含蛋白聚糖的细胞外基质的构建块，从而平衡关节软骨的分解代谢和合成代谢。已记录到硫酸氨基葡萄糖对骨关节炎人群的有益临床效果。但是，硫酸氨基葡萄糖用于治疗运动性关节软骨损伤尚未得到证实。
结论/建议：临床研究表明，硫酸氨基葡萄糖已被证明是治疗骨关节炎的一种安全且相对有效的方法。但是，迄今为止，没有证据支持或反驳它对运动人群及其在运动中发生的损伤有持续作用。
Zotero 插件