McKiernan J, Mellor D H, Court S
Clin Pediatr (Phila). 1981 Mar;20(3):208-11. doi: 10.1177/000992288102000306.
A total of 107 children who had been hospitalized following a febrile convulsion were enrolled into the trial. By random allocation, 55 children were treated with pyridoxine hydrochloride (20 mgs twice daily) and the remaining 52 children were treated with a placebo until there had been either a further convulsion or a year had passed without recurrence. Eighty children were adequately followed up and of these, 17 had a recurrent febrile convulsion while receiving medication. Recurrences occurrences occurred in 7 of the 38 children receiving pyridoxine and in 10 of the 42 children receiving placebo (X2 = .346, p greater than 0.5). Initial tryptophan load tests had been abnormal in 34 children, and of these, recurrences occurred in 3 of the 17 who received pyridoxine and in 3 of the 17 who received placebo. It has yet to be shown that pyridoxine supplementation protects children from recurrent febrile convulsions.
共有107名因热性惊厥住院的儿童被纳入该试验。通过随机分配，55名儿童接受盐酸吡哆醇治疗（每日两次，每次20毫克），其余52名儿童接受安慰剂治疗，直至再次出现惊厥或经过一年无复发。80名儿童得到了充分随访，其中17名在接受药物治疗时出现了复发性热性惊厥。接受吡哆醇治疗的38名儿童中有7名复发，接受安慰剂治疗的42名儿童中有10名复发（X2 = 0.346，p大于0.5）。34名儿童最初的色氨酸负荷试验异常，其中，接受吡哆醇治疗的17名儿童中有3名复发，接受安慰剂治疗的17名儿童中有3名复发。补充吡哆醇是否能保护儿童免受复发性热性惊厥的影响，目前尚未得到证实。
