Experimental induced bronchial hyperreactivity.

Bronchial hyperreactivity can be influenced by antigen inhalation as well as by infections which affect the bronchial tree. Bronchial hyperreactivity characterizes the obstructive airway diseases. In order to study this problem, we have performed in our laboratory a series of experiments concerning this problem. The influence of proteolytical enzymes on acetylcholine-induced bronchoconstriction was tested in a series of animals. After enzymes inhalation, an extreme enlarged answer to acetylcholine exposure was observed. Bronchial hyperreactivity induced after histamine and also after antigen administration and the influence of antihistamine was also tested in a series of experiments. The hyperreactivity of bronchial system observed after experimental pulmonary embolism was finally studied on a series of animals. The influence of vagus blockade on this induced bronchial hyperreactivity was also tested. After vagus blockade no bronchoconstrictoric answer was observed. The relation of bronchial hyperreactivity to localization of sensoric receptors can be assumed.