Allison R C, Murphy T L, Weisman I M, McCaffree D R, Gray B A
J Appl Physiol Respir Environ Exerc Physiol. 1981 Jan;50(1):185-90. doi: 10.1152/jappl.1981.50.1.185.
The effect of the serotonin antagonist methysergide on the acute lung mechanics response to endotoxin in anesthetized, paralyzed, mechanically ventilated dogs was investigated. In five dogs given 0.25 mg/kg Escherichia coli endotoxin only, the pulmonary nonelastic resistance (RL) increased to 238% of control and dynamic compliance (CL) decreased to 50% of control. In a second group of five dogs, methysergide (0.25 mg/kg) was shown to markedly attenuate the lung mechanics response to serotonin (0.04 mg/kg), which alone had produced changes in lung mechanics greater than endotoxin. In these same dogs endotoxin administered after injection of methysergide produced an increase in RL to 377% and a decrease in CL to 33% of control. In a third group of five dogs whose lung mechanics response to serotonin was also greater than to endotoxin alone, endotoxin administered after injection of saline produced an increase in RL to 168% and a decrease in CL to 58% of control. Since the response to endotoxin after injection of methysergide exceeded the response after saline, we conclude that serotonin is not a mediator of the acute lung mechanics response to endotoxin.
研究了血清素拮抗剂甲基麦角新碱对麻醉、麻痹、机械通气犬对内毒素的急性肺力学反应的影响。在仅给予0.25mg/kg大肠杆菌内毒素的5只犬中，肺非弹性阻力（RL）增加至对照的238%，动态顺应性（CL）降至对照的50%。在第二组5只犬中，甲基麦角新碱（0.25mg/kg）被证明可显著减弱对血清素（0.04mg/kg）的肺力学反应，血清素单独引起的肺力学变化大于内毒素。在这些相同的犬中，注射甲基麦角新碱后给予内毒素，导致RL增加至对照的377%，CL降至对照的33%。在第三组5只犬中，其对血清素的肺力学反应也大于单独对内毒素的反应，注射生理盐水后给予内毒素，导致RL增加至对照的168%，CL降至对照的58%。由于注射甲基麦角新碱后对内毒素的反应超过了注射生理盐水后的反应，我们得出结论，血清素不是急性肺力学对内毒素反应的介质。
