Johnson R J, Matthews J L, Stone M J, Hurt W C, Newman J T
J Periodontol. 1980 Dec;51(12):705-12. doi: 10.1902/jop.1980.51.12.705.
Eleven patients with periodontitis, ten patients with juvenile periodontitis and ten control subjects were studied to compare systemic and local immunologic responses and various other blood parameters. A more intensified immunologic response was seen in juvenile periodontitis as compared to periodontitis or controls as evidenced by: (1) greater number of plasma cells and lymphocytes in biopsy specimens of involved gingiva stained by Harris hematoxylin and eosin; (2) significant decrease in serum C4 levels and slightly elevated serum IgG levels as determined by radial immunodiffusion; (3) marked increase of positive fluorescing cells in biopsy specimens stained with antihuman immunoglobulin conjugate and an increase in complement deposition in the same tissues as determined by immunofluorescence. No significant differences among the two groups of patients and control subjects were observed with respect to complete blood counts, coagulation studies, or blood glucose levels. These findings suggest that the immunologic responses in periodontitis and juvenile periodontitis are qualitatively similar, but that the intensity of the response is greater in juvenile periodontitis.
对11名牙周炎患者、10名青少年牙周炎患者和10名对照受试者进行了研究，以比较全身和局部免疫反应以及各种其他血液参数。与牙周炎或对照相比，青少年牙周炎中观察到更强烈的免疫反应，证据如下：（1）用哈里斯苏木精和伊红染色的受累牙龈活检标本中浆细胞和淋巴细胞数量更多；（2）通过放射免疫扩散测定，血清C4水平显著降低，血清IgG水平略有升高；（3）用抗人免疫球蛋白缀合物染色的活检标本中阳性荧光细胞显著增加，并且通过免疫荧光测定，同一组织中的补体沉积增加。在两组患者和对照受试者之间，在全血细胞计数、凝血研究或血糖水平方面未观察到显著差异。这些发现表明，牙周炎和青少年牙周炎中的免疫反应在性质上相似，但青少年牙周炎中反应的强度更大。
