Punnonen R, Lammintausta R, Erkkola R, Rauramo L
Maturitas. 1980 Jul;2(2):91-4. doi: 10.1016/0378-5122(80)90041-9.
The effect of estradiol valerate (Progynova, 2 mg daily) on the renin--aldosterone system was studied in nine women after bilateral oophorectomy. Plasma renin activity (PRA) and the daily urinary excretion of aldosterone (dU-Ald) were determined 4 mth after the operation -- during which no estrogen was given -- and after 3 mth on estrogen therapy. Plasma estradiol concentration rose in 7 subjects to the normal postovulatory level. No changes were found in PRA or dU-Ald. The results suggest that an effective estradiol valerate therapy is not accompanied with activation of renin--aldosterone system, while synthetic and non-human natural estrogens (Premarin) were shown earlier to increase PRA.
在9名双侧卵巢切除术后的女性中研究了戊酸雌二醇（补佳乐，每日2毫克）对肾素 - 醛固酮系统的影响。在术后4个月（期间未给予雌激素）以及雌激素治疗3个月后测定血浆肾素活性（PRA）和醛固酮的每日尿排泄量（dU-Ald）。7名受试者的血浆雌二醇浓度升至正常排卵后水平。未发现PRA或dU-Ald有变化。结果表明，有效的戊酸雌二醇治疗不会伴随肾素 - 醛固酮系统的激活，而合成的非天然雌激素（倍美力）早些时候已显示会增加PRA。
