Lammintausta R, Kanto J, Mäntylä R
Int J Clin Pharmacol Biopharm. 1978 Nov;16(11):503-7.
Plasma renin activity (PRA), urinary aldosterone excretion (U-Ald) and electrolyte excretions were studied after a placebo (P) (n = 47) and during the following day randomly after amiloride (A) (5 mg, n = 18), hydrochlorothiazide (H) (50 mg, n = 12) and hydrochlorothiazide + amiloride tablets (HA) (50 + 5 mg, n = 19). After A no change in PRA or in U-Ald could be found in 24 hr. After H an increase in PRA was found, but not until 24 hr, and U-Ald was increased during 8--24 hr. HA possessed a higher saluretic effect than H, but the excretion of potassium was lower. PRA increased in 8 hr after HA and a further increase was seen until 24 hr. U-Ald had already increased after HA during 0--8 hr, and U-ALD was higher during 8--24 hr and 0--24 hr than after H. After HA a positive correlation was found between the increases of sodium excretion and PRA; between U-Ald and PRA a positive correlation was also found; but between potassium excretion and PRA or U-Ald there was no correlation. The results suggest the priority of natriuresis in the regulation of renin release after H and HA. The stronger reaction of the renin-aldosterone system after HA than after H thus may result from the faster and higher natriuretic potency of this combination in acute study.
研究了安慰剂（P）组（n = 47）以及在服用阿米洛利（A）（5 mg，n = 18）、氢氯噻嗪（H）（50 mg，n = 12）和氢氯噻嗪 + 阿米洛利片（HA）（50 + 5 mg，n = 19）后的第二天随机分组后的血浆肾素活性（PRA）、尿醛固酮排泄量（U-Ald）和电解质排泄情况。服用A后24小时内PRA或U-Ald未发现变化。服用H后发现PRA升高，但直到24小时才出现，且U-Ald在8 - 24小时内升高。HA的利钠作用比H更强，但钾排泄量更低。服用HA后8小时PRA升高，直至24小时进一步升高。服用HA后0 - 8小时U-Ald已经升高，且在8 - 24小时和0 - 24小时内U-ALD高于服用H后。服用HA后，钠排泄量增加与PRA之间呈正相关；U-Ald与PRA之间也呈正相关；但钾排泄量与PRA或U-Ald之间无相关性。结果表明，H和HA后肾素释放调节中利钠作用优先。HA后肾素 - 醛固酮系统的反应比H后更强，这可能是由于该组合在急性研究中利钠作用更快、更强。
