Erkkola R, Lammintausta R, Punnonen R, Rauramo L
Maturitas. 1978 Jun;1(1):9-14. doi: 10.1016/0378-5122(78)90004-x.
The effects of estriol succinate (Synapause, 2 mg daily) on the renin-aldosterone system and blood pressure (RR) were studied in 14 postmenopausal women after bilateral oophorectomy. Plasma renin activity (PRA) and daily urinary aldosterone excretion (dU-Ald) were determined 1 mth after the operation and before estrogen treatment, at the end of 2 mth therapy, and, for the third time, 2 mth after the termination of treatment with the drug. No changes in PRA, dU-Ald or RR were found in normotensive women, or in 3 women with hypertension in this group. Another group of 11 postmenopausal women was investigated after long-term estriol succinate therapy, which had lasted for 5-8 yr after oophorectomy. PRA, dU-Ald and RR were measured during treatment and 2 mth after terminating the therapy. No changes were found either in hormone differences in the mean levels of PRA or dU-Ald. The results suggest that estriol succinate is devoid of general harmful effects on the renin-aldosterone system during postmenopausal therapy for climacteric symptoms.
在14名双侧卵巢切除术后的绝经后妇女中，研究了琥珀酸雌三醇（Synapause，每日2毫克）对肾素 - 醛固酮系统和血压（RR）的影响。在术后1个月且在雌激素治疗前、治疗2个月结束时以及在停药2个月后第三次测定血浆肾素活性（PRA）和每日尿醛固酮排泄量（dU - Ald）。在血压正常的妇女或该组中3名高血压妇女中，未发现PRA、dU - Ald或RR有变化。另一组11名绝经后妇女在长期琥珀酸雌三醇治疗后进行了调查，该治疗在卵巢切除术后持续了5至8年。在治疗期间和停药2个月后测量了PRA、dU - Ald和RR。在PRA或dU - Ald平均水平的激素差异方面均未发现变化。结果表明，在绝经后治疗更年期症状期间，琥珀酸雌三醇对肾素 - 醛固酮系统无普遍有害影响。
