一种在细菌DNA不连续复制中具有活性的质粒DNA引发酶。
A plasmid DNA primase active in discontinuous bacterial DNA replication.
作者信息
Wilkins B M, Boulnois G J, Lanka E
出版信息
Nature. 1981 Mar 19;290(5803):217-21. doi: 10.1038/290217a0.
DOI:10.1038/290217a0
PMID:7010183
Abstract
A DNA primase encoded by an IncI alpha plasmid promotes efficient DNA replication in a primase-defective mutant of Escherichia coli. This finding implies that the plasmid enzyme can prime discontinuous DNA synthesis of the bacterial chromosome. The plasmid gene encodes two large, antigenically related proteins which differ from E. coli primase.
摘要
由IncIα质粒编码的一种DNA引发酶可促进大肠杆菌引发酶缺陷型突变体中的高效DNA复制。这一发现表明，该质粒酶可引发细菌染色体的不连续DNA合成。该质粒基因编码两种与大肠杆菌引发酶不同的、抗原相关的大蛋白。
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