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类风湿关节炎患者的中性粒细胞迁移(作者译)

[Neutrophil migration in patients with rheumatoid arthritis (author's transl)].

作者信息

Seigneurin D, Montserrat C, Blanc D, Phelip X

出版信息

Pathol Biol (Paris). 1981 Jan;29(1):19-24.

PMID:7010272
Abstract

The leukocyte mobilization "in vivo" was assayed in 16 patients with rheumatoid arthritis and 10 normal subjects using the modified Senn's technique. The rate of leukocytes mobilization (LMR) is variable: in 5 cases lower than normal. No correlation is found with latex or Waaler-Rose titer, total complement in the serum, but the lowest rates of leukocyte mobilization are in previously treated patients. After 48 hours of indomethacin treatment, the LMR decreases significantly both in the patients and in the normal subjects. These results show that the abnormal "in vivo" LMR is more related to drug therapy than disease.

摘要

采用改良的森氏技术,对16例类风湿性关节炎患者和10名正常受试者进行了“体内”白细胞动员检测。白细胞动员率(LMR)各不相同:5例低于正常水平。未发现其与乳胶或瓦勒 - 罗斯滴度、血清总补体相关,但白细胞动员率最低的是先前接受过治疗的患者。吲哚美辛治疗48小时后,患者和正常受试者的LMR均显著下降。这些结果表明,异常的“体内”LMR与药物治疗的关系比与疾病的关系更大。

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