体内注射前列环素（PGI2）特异性抗体表明，内源性PGI2在正常血压和自发性高血压大鼠中并非作为循环血管舒张激素发挥作用。

PGI2-specific antibodies administered in vivo suggest against a role for endogenous PGI2 as a circulating vasodepressor hormone in the normotensive and spontaneously hypertensive rat.

作者信息

Pace-Asciak C R, Carrara M C, Levine L, Nicolaou K C

出版信息

Prostaglandins. 1980 Dec;20(6):1053-60. doi: 10.1016/0090-6980(80)90059-3.

Abstract

Immunoglobulins raised against 5,6-dihydro PGI2 crossreact with PGI2. When infused in vivo into the rat, these immunoglobulins are capable of 1) neutralising the vasodepressor effects (bolus or continuous infusion) of exogenous PGI2, 2) blocking the catabolism of exogenous 3H-PGI2 and prolonging its life-time in the circulation (t 1/2 approx 60 min) while that of 3H-PGE2 is unaffected, 3) trapping an endogenously produced substance which after extraction from blood and dissociation from the ligand-antibody complex, is immunoreactive with 6-keto PGF1 alpha-specific antiserum. Yet the anti-5,6-dihydro PGI2 immunoglobulins have no effect on resting arterial blood pressure both in the normotensive and spontaneously hypertensive rat. These experiments indicate that endogenously produced PGI2 does not play a significant systemic role in blood pressure control although in combination with other vasodilators it could still participate in the regulation of vascular tone at a local level.

摘要

针对5,6-二氢前列环素（PGI2）产生的免疫球蛋白与PGI2发生交叉反应。当将这些免疫球蛋白体内注入大鼠时，它们能够：1）中和外源性PGI2的血管降压作用（推注或持续输注）；2）阻断外源性3H-PGI2的分解代谢并延长其在循环中的寿命（半衰期约60分钟），而3H-前列腺素E2（PGE2）的半衰期不受影响；3）捕获一种内源性产生的物质，该物质从血液中提取并与配体-抗体复合物解离后，与6-酮-前列腺素F1α特异性抗血清发生免疫反应。然而，抗5,6-二氢PGI2免疫球蛋白对正常血压和自发性高血压大鼠的静息动脉血压均无影响。这些实验表明，内源性产生的PGI2在血压控制中不发挥重要的全身作用，尽管它与其他血管舒张剂结合仍可能在局部水平参与血管张力的调节。