Eling T E, Ally A I
Environ Health Perspect. 1984 Apr;55:159-68. doi: 10.1289/ehp.8455159.
On passage through the lung vascular bed, prostaglandins are removed from the circulation by a transport carrier and subsequently inactivated by intracellular enzymes. However, PGI2 is not inactivated by the lung in vivo. Although PGI2 is an excellent substrate for the intracellular enzymes in vitro, PGI2 is not a substrate for the carrier system. Thus, the transport carrier determines which circulating prostaglandin is inactivated by the pulmonary vascular bed. Also, the lung has a high capacity for forming prostaglandins from arachidonic acid. Considerable differences exist between species in relation to amount and specific prostaglandin formed as determined by incubation of 11C-PGH2 with pulmonary microsomes. The pulmonary biosynthesis and metabolism of these prostaglandins and related substances are discussed.
在通过肺血管床的过程中，前列腺素通过转运载体从循环中清除，随后被细胞内酶灭活。然而，前列环素（PGI2）在体内不会被肺灭活。尽管在体外PGI2是细胞内酶的优良底物，但PGI2不是载体系统的底物。因此，转运载体决定了哪种循环前列腺素会被肺血管床灭活。此外，肺从花生四烯酸形成前列腺素的能力很强。用11C - PGH2与肺微粒体孵育所确定的，不同物种在前列腺素生成量和特定前列腺素种类方面存在相当大的差异。本文讨论了这些前列腺素及相关物质的肺生物合成和代谢。
