自发性高血压大鼠的血压变化与主动脉前列环素的生成相关。
Blood pressure changes in spontaneously hypertensive rats correlate with aortic prostacyclin formation.
作者信息
Fahr A, Förster W, Taube C
出版信息
Br J Pharmacol. 1983 May;79(1):19-21. doi: 10.1111/j.1476-5381.1983.tb10490.x.
Abstract
1 The relationship between the blood pressure fall, induced by antihypertensive drugs or bleeding, and the formation of prostacyclin (PGI2)-like activity in the thoracic aorta of spontaneously hypertensive rats has been investigated. Inhibition of ADP-induced platelet aggregation was used to assess PGI2-like activity. 2 The decreases in blood pressure produced by clonidine, dihydralazine and prazosin were associated with increases of PGI2-like activity of 50-80%. The increase in PGI2-like activity correlated well with the blood pressure decrease, independently of the mechanism of the fall in blood pressure.
摘要
- 已经研究了抗高血压药物或放血诱导的血压下降与自发性高血压大鼠胸主动脉中前列环素（PGI2）样活性形成之间的关系。使用抑制ADP诱导的血小板聚集来评估PGI2样活性。2. 可乐定、双肼屈嗪和哌唑嗪引起的血压下降与PGI2样活性增加50 - 80%相关。PGI2样活性的增加与血压下降密切相关，与血压下降的机制无关。
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本文引用的文献
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