ATP-氯化镁处理对肾脏保存及移植物功能恢复的影响。

Effect of ATP-MgCl2 treatment on kidney preservation and on recovery of graft function.

作者信息

Horpàcsy G, Gàl G, Kiss E, Tutsek L, Szabò I

出版信息

Res Exp Med (Berl). 1980;178(1):3-9. doi: 10.1007/BF01856752.

Abstract

The effect of ATP-MgCl2 treatment was investigated on the biochemical changes of preserved kidneys and on the functional recovery of hypoxically damaged and autotransplanted canine kidneys. We observed that ATP-MgCl2 administered before or during simple hypothermic storage did not protect the integrity of preserved kidney cells, as measured by enzyme wash-out (LDH and NAG) or by lactate release. If the compound was administered after 120 min or 180 min clamping of the renal artery, the solitary kidney showed a faster regeneration as measured by changes in serum creatinine level. The survival rates were significantly higher in the treated groups. Without warm ischemia of the kidney all of the autotransplanted dogs survived after surgery. After 60 min of warm ischemia the mortality rate was 100%, and the mean survival time in average 5 days. If ATP-MgCl2 was administered after the 60 min of warm ischemia, an improved recovery of the graft function was observed

摘要

研究了ATP-MgCl₂处理对保存肾脏的生化变化以及对缺氧损伤和自体移植犬肾功能恢复的影响。我们观察到，在单纯低温保存之前或期间给予ATP-MgCl₂，并不能保护保存的肾细胞的完整性，这通过酶洗脱（乳酸脱氢酶和N-乙酰-β-D-氨基葡萄糖苷酶）或乳酸释放来衡量。如果在肾动脉夹闭120分钟或180分钟后给予该化合物，通过血清肌酐水平的变化来衡量，孤肾显示出更快的再生。治疗组的存活率显著更高。在没有肾脏热缺血的情况下，所有自体移植的狗术后均存活。热缺血60分钟后，死亡率为100%，平均存活时间平均为5天。如果在热缺血60分钟后给予ATP-MgCl₂，则观察到移植肾功能有改善的恢复。