持续低温肾灌注期间人白蛋白灌注介质中pH值变化的意义。

The significance of pH variations in human albumin perfusion media during continuous hypothermic renal perfusion.

作者信息

Olsen P R, Krarup T, Faurby V, Larsen N A, Larsen S

出版信息

Scand J Urol Nephrol. 1980;14(3):288-91. doi: 10.3109/00365598009179578.

Abstract

The variation of pH in perfusate during renal machine perfusion has been regarded exclusively as an effect of kidney metabolism. During preservation of 21 canine kidneys for 48 hours in a Gambro PF-2D machine the pH was measured in the human albumin perfusion medium used, and in control samples stored a 4 degrees C. An increase in pH from 7.21 (+/- 0.03) to 7.66 (+/- 0.10) was found in the machine perfusate. In the stored perfusion medium an increase from 7.21 (+/- 0.03) to 7.43 (+/- 0.20) was measured. We conclude that the pH change in perfusate is not a reliable parameter for the functional state of the kidney unless the spontaneous pH variation in the perfusion medium is simultaneously recorded and a correction made.

摘要

在肾脏机器灌注过程中，灌注液pH值的变化一直被单纯视为肾脏代谢的一种效应。在使用 Gambro PF - 2D 机器对 21 个犬肾进行 48 小时保存期间，对所用的人白蛋白灌注介质以及在 4℃储存的对照样本进行了pH值测量。发现机器灌注液的pH值从 7.21（±0.03）升高到 7.66（±0.10）。在储存的灌注介质中，测量到pH值从 7.21（±0.03）升高到 7.43（±0.20）。我们得出结论，除非同时记录灌注介质中的自发pH值变化并进行校正，否则灌注液中的pH值变化并非评估肾脏功能状态的可靠参数。