Posadas C, Boyer J L, Guzmán J, Figueroa J, Millán A, Sánchez G, Serrano P A
Arch Inst Cardiol Mex. 1981 Jan-Feb;51(1):13-9.
The effects of dopamine, its precursor L-dopa, and the dopaminergic agonist bromocriptine (BEC), on plasma renin activity (PRA), in pentobarbital anesthetized male dogs were investigated. Infusion of dopamine at a dose which did not change blood pressure ( 4 ug/kg/min) had no effect on the secretion of renin, nor did it produce modifications in the PRA response to furosemide (10 mg i.v.). L-dopa, in single dose of 500 mg (p.o), significantly augmented PRA two hours after administration, and the renin values remained elevated throughout the observation period of 120 minutes. However, BEC (2.5 mg p.o.) produced no changes in PRA during this time period. We conclude that at the dose utilized, dopamine apparently has no influence on the secretion of renin, and does not modify the increase in PRA provoked by diuretic. It is possible that the L-dopa induced augmentation in PRA is due to stimulation of the juxtaglomerular cells, by the noradrenaline formed in peripheral tissues from administered L-dopa.
研究了多巴胺、其前体左旋多巴以及多巴胺能激动剂溴隐亭（BEC）对戊巴比妥麻醉的雄性犬血浆肾素活性（PRA）的影响。以不改变血压的剂量（4微克/千克/分钟）输注多巴胺对肾素分泌无影响，对呋塞米（静脉注射10毫克）引起的PRA反应也无改变。口服500毫克单剂量的左旋多巴在给药两小时后显著提高了PRA，并且在120分钟的观察期内肾素值一直保持升高。然而，在此时间段内，口服2.5毫克BEC对PRA没有产生变化。我们得出结论，在所使用的剂量下，多巴胺显然对肾素分泌没有影响，并且不会改变利尿剂引起的PRA升高。左旋多巴诱导的PRA升高可能是由于给药的左旋多巴在外周组织中形成的去甲肾上腺素刺激了肾小球旁细胞。
