Neborsky R, Janowsky D, Munson E, Depry D
Arch Gen Psychiatry. 1981 Feb;38(2):195-9. doi: 10.1001/archpsyc.1981.01780270081011.
Twenty acutely psychotic male psychiatric inpatients were assigned to two groups and treated with high- and low-dose haloperidol using a rapid neuroleptization technique. A six-day maintenance phase followed. Both groups improved at one hour, one day, and seven days after starting treatment, and neither group differed as to degree or rapidity of symptom alleviation. Therefore, the results of the study do not give experimental support for the administration of high doses of haloperidol to young, acutely psychotic inpatients with relatively good prognoses.
20名急性精神病发作的男性精神科住院患者被分为两组，采用快速神经安定化技术分别接受高剂量和低剂量的氟哌啶醇治疗。随后是为期六天的维持阶段。两组患者在开始治疗后1小时、1天和7天均有改善，且在症状缓解程度或速度方面两组无差异。因此，该研究结果并不支持对预后相对较好的年轻急性精神病住院患者使用高剂量氟哌啶醇。
