APURV KHANNA, M.B.B.S., Ex-Resident, Department of Psychiatry, K.G. Medical College, Lucknow-226003.
Indian J Psychiatry. 1997 Apr;39(2):136-42.
The apparent rationale for the popular use of high doses of neuroleptics in psychotic patients is to increase the degree and speed of therapeutic response .However, several recent reports have questioned these claims. The present study was undertaken with the aim to compare the efficacy of high and low oral doses of haloperidol in the treatment of acute and transient psychotic disorders. The sample comprised of forty patients of both sexes diagnosed as acute and transient psychotic disorder who were randomly assigned to high dose (20 mg/day) and low dose (5 mg /day) haloperidol groups with equal number of subjects (n=20) in both groups. Weekly assessment was done on Brief Psychiatric Rating Scale and Haloperidol Side-effects Check List (day 7, 14, 21, 28, 35 & 42). Both groups showed significant improvement in BPRS from baseline scores on all assessments. Comparison of the improvement rate in both study groups revealed no significant difference.
将抗精神病药物的高剂量广泛应用于精神病患者的明显理由是增加治疗反应的程度和速度。然而，最近有几项报告对这些说法提出了质疑。本研究旨在比较高剂量和低剂量氟哌啶醇治疗急性和短暂性精神病的疗效。该样本包括 40 名男女患者，均被诊断为急性和短暂性精神病障碍，随机分为高剂量（20 毫克/天）和低剂量（5 毫克/天）氟哌啶醇组，每组 20 名受试者。每周使用简明精神病评定量表和氟哌啶醇副作用检查表进行评估（第 7、14、21、28、35 和 42 天）。两组患者的 BPRS 评分均在所有评估中从基线分数开始显著改善。比较两组研究对象的改善率，没有发现显著差异。
