Kanzaki J, O-Uchi T
Acta Otolaryngol Suppl. 1983;393:77-84. doi: 10.3109/00016488309129581.
Immune complexes (IC) were determined quantitatively in 53 cases of bilateral sensorineural hearing loss (SNHL) by the Raji cell immuno-fluorescence assay. The 53 cases consisted of 47 cases of unknown etiology, 5 cases with positive syphilitic reaction and 1 case of aortitis syndrome. High IC values were indicated in 5 cases, of which one was of aortitis syndrome and 4 were of unknown etiology. The case of aortitis syndrome and 3 out of the above 4 cases of unknown etiology were responsive to steroid. There were 2 cases which showed normal IC values but reacted to steroid. All patients of the steroid-responsive SNHL were female. If hearing improves by steroid administration, it is necessary to suspect autoimmune SNHL. It has been proved that in SNHL which is responsive to steroid, the hearing level before the start of treatment may be maintained by long-term steroid therapy.
通过Raji细胞免疫荧光测定法对53例双侧感音神经性听力损失（SNHL）患者的免疫复合物（IC）进行了定量测定。这53例患者包括47例病因不明者、5例梅毒反应阳性者和1例主动脉炎综合征患者。5例IC值较高，其中1例为主动脉炎综合征，4例病因不明。主动脉炎综合征患者及上述4例病因不明患者中的3例对类固醇治疗有反应。有2例IC值正常但对类固醇有反应。所有对类固醇有反应的SNHL患者均为女性。如果使用类固醇治疗后听力改善，则有必要怀疑自身免疫性SNHL。已经证明，在对类固醇有反应的SNHL中，长期类固醇治疗可维持治疗开始前的听力水平。
