Frelinger J G, Frelinger J A, Hood L
Immunogenetics. 1981 Mar 1;12(5-6):569-77. doi: 10.1007/BF01561697.
Peptide map comparisons of molecules encoded in the mouse H-2 complex isolated from epidermal cell preparations have been carried out. We previously showed that the Ia molecules from both the I-A and I-E subregions are synthesized by nonlymphoid bone-marrow-derived cells, probably Langerhans cells. The K and D or transplantation molecules are synthesized by both "true" epidermal cells and nonlymphoid bone-marrow-derived cells. The tryptic maps generated by separating tryptic peptides by high pressure liquid chromatography (HPLC) of epidermal H-2 molecules are identical to their spleen-cell counterparts. The biological significance of this finding is discussed.
已对从小鼠表皮细胞制剂中分离出的H-2复合体所编码分子进行了肽图比较。我们先前表明，I-A和I-E亚区的Ia分子是由非淋巴细胞骨髓来源的细胞合成的，可能是朗格汉斯细胞。K和D移植分子由“真正的”表皮细胞和非淋巴细胞骨髓来源的细胞合成。通过高压液相色谱（HPLC）分离表皮H-2分子的胰蛋白酶肽所生成的胰蛋白酶图谱与其脾细胞对应物相同。讨论了这一发现的生物学意义。
