一种由与主要组织相容性复合体连锁的基因所决定的小鼠B细胞同种抗原。
A mouse B-cell alloantigen determined by gene(s) linked to the major histocompatibility complex.
作者信息
Sachs D H, Cone J L
出版信息
J Exp Med. 1973 Dec 1;138(6):1289-304. doi: 10.1084/jem.138.6.1289.
Abstract
Antibodies cytotoxic for only a subpopulation of C57Bl/10 lymph node and spleen cells were detected when rat antiserum against B10.D2 was exhaustively absorbed with B10.A lymphocytes. Antibodies of similar specificity were also detected in B10.A anti-B10.D2 and in B10.A anti-C57Bl/10 alloantisera. Reactions with recombinant strains of mice indicate that the cell-surface antigen(s) responsible for this specificity is determined by gene(s) in or to the left of the Ir-1 region of the major histocompatibility complex. A variety of criteria implicate B cells as the subpopulation of lymphocytes bearing this antigen. In view of these data and the recent report by others of a T-cell alloantigen determined by gene(s) in the major histocompatibility complex, it seems possible that there may be a variety of H-2-linked alloantigens expressed preferentially on subclasses of lymphocytes.
摘要
当用B10.A淋巴细胞彻底吸收抗B10.D2大鼠抗血清时，检测到仅对C57Bl/10淋巴结和脾细胞亚群具有细胞毒性的抗体。在B10.A抗B10.D2以及B10.A抗C57Bl/10同种抗血清中也检测到了具有相似特异性的抗体。与重组小鼠品系的反应表明，负责这种特异性的细胞表面抗原是由主要组织相容性复合体Ir-1区域内或其左侧的基因所决定的。多种标准表明B细胞是携带这种抗原的淋巴细胞亚群。鉴于这些数据以及其他人最近关于主要组织相容性复合体中的基因决定T细胞同种异体抗原的报告，似乎有可能存在多种优先在淋巴细胞亚类上表达的H-2连锁同种异体抗原。
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