补体对人白细胞对免疫复合物的化学发光反应的影响。
Influence of complement on the chemiluminescent response of human leukocytes to immune complex.
作者信息
Löfgren S, Tärnvik A, Carlsson J
出版信息
Infect Immun. 1980 Aug;29(2):335-41. doi: 10.1128/iai.29.2.335-341.1980.
Abstract
Vaccine bacteria of Francisella tularensis were mixed with human serum containing specific antibodies against the same organism, and the mixture was incubated at 37 degrees C for 30 min. The mixture induced a two-peak chemiluminescent response in polymorphonuclear leukocytes. The initial peak was induced by a soluble agent, formed during incubation. The formation of this agent involved the activation of complement component C5. The second peak of the chemiluminescent response was induced by the opsonized bacteria; this peak was augmented by complement component C3, whereas C5 had no influence.
摘要
将土拉弗朗西斯菌疫苗菌与含有针对同一生物体的特异性抗体的人血清混合，并将混合物在37℃下孵育30分钟。该混合物在多形核白细胞中诱导出双峰化学发光反应。初始峰由孵育过程中形成的一种可溶性因子诱导。该因子的形成涉及补体成分C5的激活。化学发光反应的第二个峰由调理素化细菌诱导；该峰由补体成分C3增强，而C5没有影响。
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本文引用的文献
1
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J Exp Med. 1965 Aug 1;122(2):277-98. doi: 10.1084/jem.122.2.277.
2
Characterization of lactic dehydrogenase of normal human granulocytes.正常人粒细胞乳酸脱氢酶的特性研究
J Lab Clin Med. 1963 May;61:713-23.
3
4
Studies on the fibrinogen, dextran and phytohemagglutinin methods of isolating leukocytes.关于纤维蛋白原、右旋糖酐和植物血凝素分离白细胞方法的研究。
Blood. 1956 May;11(5):436-54.
5
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