胰岛素受体代谢的调节。分化诱导的受体合成与降解的改变。 - Suppr

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Regulation of insulin receptor metabolism. Differentiation-induced alteration of receptor synthesis and degradation.

作者信息

Reed B C, Ronnett G V, Clements P R, Lane M D

出版信息

J Biol Chem. 1981 Apr 25;256(8):3917-25.

PMID:7012145

Abstract

摘要

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Regulation of insulin receptor metabolism. Differentiation-induced alteration of receptor synthesis and degradation.胰岛素受体代谢的调节。分化诱导的受体合成与降解的改变。

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Endoplasmic reticulum stress causes insulin resistance by inhibiting delivery of newly synthesized insulin receptors to the cell surface.内质网应激通过抑制新合成的胰岛素受体向细胞表面转运而导致胰岛素抵抗。

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Control of insulin receptor level in 3T3 cells: effect of insulin-induced down-regulation and dexamethasone-induced up-regulation on rate of receptor inactivation.3T3细胞中胰岛素受体水平的调控：胰岛素诱导的下调和地塞米松诱导的上调对受体失活速率的影响。

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Adipose cell differentiation in culture.培养中的脂肪细胞分化。

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