• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

苯致畸学的现状:简要综述

Current status of benzene teratology: a brief review.

作者信息

Mehlman M A, Schreiner C A, Mackerer C R

出版信息

J Environ Pathol Toxicol. 1980 Nov;4(5-6):123-31.

PMID:7012268
Abstract

This article summarizes the results of experimental studies on teratogenesis associated with exposure to benzene by oral, parenteral or inhalation routes. Administration of benzene to pregnant experimental animals did not produce marked developmental effects in the fetus at concentrations which did not cause concomitant maternal toxicity. Thus, at maternally nontoxic levels, benzene does not constitute a teratogenic hazard.

摘要

本文总结了经口、胃肠外或吸入途径接触苯所致致畸作用的实验研究结果。给怀孕的实验动物施用苯,在未引起母体毒性的浓度下,未对胎儿产生明显的发育影响。因此,在母体无毒的水平下,苯不构成致畸危害。

相似文献

1
Current status of benzene teratology: a brief review.苯致畸学的现状:简要综述
J Environ Pathol Toxicol. 1980 Nov;4(5-6):123-31.
2
Maternal and fetal toxicity of N-methylmorpholine by oral administration in rats.大鼠口服 N-甲基吗啉的母胎毒性
Teratog Carcinog Mutagen. 1999;19(6):369-76.
3
Developmental toxicity of two trimethylbenzene isomers, mesitylene and pseudocumene, in rats following inhalation exposure.吸入暴露后大鼠体内均三甲苯和偏三甲苯这两种三甲苯异构体的发育毒性
Food Chem Toxicol. 2005 Jul;43(7):1055-63. doi: 10.1016/j.fct.2005.02.008.
4
[Atmospheric pollutants and pregnancy: fetal toxicity of exposure to air polluted by combustion engine gas].
Boll Soc Ital Biol Sper. 1985 Jun 30;61(6):903-7.
5
Placental transfer and teratology of pentachlorophenol in rats.大鼠中五氯苯酚的胎盘转运与致畸学
Environ Lett. 1975;10(2):121-8. doi: 10.1080/00139307509435815.
6
Concentration dependence of the embryotoxic effects of benzene inhalation in CFY rats.CFY大鼠吸入苯的胚胎毒性作用的浓度依赖性
J Hyg Epidemiol Microbiol Immunol. 1980;24(3):363-71.
7
Critical period for a teratogenic VLA-4 antagonist: Developmental effects and comparison of embryo drug concentrations of teratogenic and non-teratogenic VLA-4 antagonists.致畸性VLA-4拮抗剂的关键时期:致畸性和非致畸性VLA-4拮抗剂的发育影响及胚胎药物浓度比较
Birth Defects Res B Dev Reprod Toxicol. 2004 Apr;71(2):69-79. doi: 10.1002/bdrb.20000.
8
Occurrence of embryotoxicity in mouse embryos following in utero exposure to 2'-deoxycoformycin (pentostatin).
Teratology. 1993 Jan;47(1):17-27. doi: 10.1002/tera.1420470106.
9
[The teratogenic action of parbendazole].[巴苯达唑的致畸作用]
Therapie. 1976 Jul-Aug;31(4):491-503.
10
Environmental causes of human congenital malformations: the pediatrician's role in dealing with these complex clinical problems caused by a multiplicity of environmental and genetic factors.人类先天性畸形的环境成因:儿科医生在应对由多种环境和遗传因素引发的这些复杂临床问题中的作用。
Pediatrics. 2004 Apr;113(4 Suppl):957-68.

引用本文的文献

1
Multiple-site carcinogenicity of benzene in Fischer 344 rats and B6C3F1 mice.苯在Fischer 344大鼠和B6C3F1小鼠中的多部位致癌性。
Environ Health Perspect. 1989 Jul;82:125-63. doi: 10.1289/ehp.8982125.